@import url('https://fonts.googleapis.com/css2?family=Open+Sans:wght@300;400;500;600;700;800&display=swap');

* {
    box-sizing: border-box;
}

:root {
    --Section-2-L-R-Padding: 120px;
}

img {
    max-width: 100%;
}

body {
    margin: 0;
    padding: 0;
    font-family: 'Open Sans', sans-serif;
    -webkit-font-smoothing: antialiased;
    font-size: 16px;
    color: #50534C;

}

sup {
    line-height: 0;
    font-size: .65em;

}

a {
    color: #0047C7;
    font-weight: bold;
    text-decoration: underline;
}

h2 {
    color: var(--Blue, #0047C7);
    text-align: center;
    font-size: 24px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    letter-spacing: -0.75px;
    margin: 0;
}

h3 {
    color: #5A5D55;
    font-size: 16px;
    margin-bottom: 0px;
}



.container {
    max-width: 1300px;
    margin: 0 auto;
    padding: 0 20px;
}


.wrapper {
    max-width: 1100px;
    margin: 30px auto;
    margin-bottom: 60px;
}

.row {
    margin: 0 -20px;
    display: flex;
    flex-wrap: wrap;
}

.row.spacer {
    margin: 0;
}


.nowrap {
    white-space: nowrap;
}


.utility {
    background-color: #002974;
    color: #fff;
    width: 100%;
    padding: 25px 0;
    position: relative;
}

.utility .row {
    align-items: center;
    justify-content: space-between;

}

.utility .col {
    padding: 0px 20px;
}

.utility .txt-r {
    text-align: right;

}



.utility .hamburger {
    position: absolute;
    right: 0;
    top: 50%;
    transform: translateY(-50%);
    display: none;
}

.utility .mobile-menu {
    background-color: #002974;
    position: absolute;
    top: 100%;
    left: 0;
    width: 100%;
    overflow: hidden;
    max-height: 0px;
    display: none;
    transition: all .3s ease-out;
    z-index: 100;
}

.utility .mobile-menu ul li {
    display: block;
    width: 100%;
    padding: 15px 20px;
}

@media screen and (max-width:1156px) {
    .utility .txt-r {
        display: none;
    }

    .utility .hamburger {
        display: inline-block;
    }

    .utility .mobile-menu {
        display: block;

    }

    .utility .mobile-menu.active {
        display: block;
        max-height: 1000px;
        transition: all .3s ease-in;
    }
}

.utility ul {
    margin: 0;
    padding: 0;
}

.utility ul li {
    list-style: none;
    display: inline-block;
    padding: 0 10px;
    margin: 0;
}

.utility a {
    color: #fff;
    font-weight: bold;
    text-decoration: underline;
    font-size: 12px;
}

.utility .signup {
    font-size: 12px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    margin-right: 5px;
}

.utility .signupbtn {
    border-radius: 8px;
    border: 1px solid #FFF;

    background: var(--Dark-Orange, #EA7603);
    box-shadow: 0px 3px 4px 0px rgba(0, 0, 0, 0.20);
    display: inline-block;
    padding: 5px 12px;
    color: #FFF;

    font-family: "Open Sans";
    font-size: 13px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    text-decoration: none;
}

.hcp-text {
    display: block;
    font-size: 12px;
}

.hero {
    padding: 40px 0 60px 0;
    background-image: url('./images/hero-background-v2.png');
    background-position: center;
    background-repeat: no-repeat;
    background-size: cover;
    text-align: center;
    box-shadow: 0 8px 12px rgba(0, 57, 109, .17);
    position: relative;
    z-index: 3;
}

.hero-content {
    max-width: 530px;
    margin: 0 auto;
}

.hero-content .btn {
    margin-left: 5px;
    margin-right: 5px;
}

.hero h1 {
    /*
    background: -webkit-linear-gradient(#FFA40D, #EA7603);
    -webkit-background-clip: text;
    -webkit-text-fill-color: transparent;
    */

    color: #EA7603;
    font-weight: 900;
    font-size: 28px;
    line-height: 34px;
    margin: 0;
    margin-bottom: 10px;
}

.hero p {
    font-size: 16px;
    color: #50534C;
    margin-top: 5px;
}

.btn {
    background-image: linear-gradient(72deg, #0047C7 0%, #74A6FF 100%);
    border-radius: 39px;
    display: inline-block;
    font-weight: bold;
    font-size: 16px;
    color: #fff;
    padding: 15px 30px;
    text-decoration: none;
    margin-bottom: -50%;
    outline: none;
    border: 0px;
    cursor: pointer;
}

.btn.secondary {
    background: #979797;
}

.wrapper .row {
    text-align: center;
}

.wrapper .row .col {
    padding: 0 20px;
    margin-top: 30px;
}

.wrapper .row .col.w-3 {
    width: 33.333%
}


.wrapper .row .col p {
    font-weight: 200;
    margin-top: 10px;
}


.resource {

    display: flex;
    align-items: center;
    text-align: left;
}


.resource img {
    vertical-align: middle;
}

.resource span {
    margin-left: 10px;
    font-size: 14px;
    color: #0062E0;
    text-decoration: underline;
}

.isi {
    background: #F9F9F9;
    padding: 30px 0;
    width: 100%;
    position: relative;
}



.isi .reference {
    padding-top: 20px;

}

.isi .reference p {
    font-size: 14px;
}

.isi .reference p a {
    color: #50534C;
    font-weight: normal;
}

.isi .title {
    color: #0062E0;
    font-weight: bold;
    font-size: 20px;
}

.isi p {
    color: #50534C;
}

.isi.fixed {
    position: fixed;
    width: 100%;
    height: calc(10em + 30px);
    bottom: 0;
    left: 0;
    z-index: 10;
    overflow: hidden;
    transition: height .4s ease;
    box-shadow: 0 -8px 12px 0 rgba(0, 57, 109, 0.17);


}

.isi.fixed.hide {
    opacity: 0;
    pointer-events: none;
}

.isi .container {
    position: relative;
}

.isi .expand {
    position: absolute;
    right: 0;
    top: 0;
    transition: all .3s ease;
    cursor: pointer;
    padding: 10px;
}

.isi.fixed.expanded {
    height: 70vh !important;
    overflow: scroll;
}

.isi.fixed.expanded .expand {
    transform: rotate(180deg);
}


footer {
    width: 100%;
    padding: 30px 20px;
    background-image: linear-gradient(270deg, #002973 55%, #011D4F 100%);
}

footer .col.end {
    flex: 1;

}

.footer-nav {
    margin: 0;
    padding: 0;
    text-align: right;
}

.footer-nav li {
    display: inline-block;
    margin: 0;
    list-style: none;
    padding: 0;
}

.footer-nav li:not(:last-child):after {
    content: '|';
    display: inline-block;
    padding: 0 20px;
    color: #fff;
}



.footer-nav li a {
    color: #fff;
    font-weight: 600;
}

.copyright {
    text-align: center;
    margin: 20px 0;
    color: #fff;
}


.cookie-modal {
    background-color: rgba(0, 0, 0, .5);
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    z-index: 100;
    height: 100vh;
}

.form-modal {
    background-color: rgba(0, 0, 0, .5);
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    z-index: 100;
    height: 100vh;
}


.hcp-modal,
.ty-modal {
    background-color: rgba(0, 0, 0, .5);
    position: fixed;
    top: 0;
    left: 0;
    width: 100%;
    height: 100%;
    z-index: 100;
    height: 100vh;
}

.form-modal .close-abs {
    position: absolute;
    top: 30px;
    right: 30px;
    cursor: pointer;
}


.modal {
    box-shadow: 0 2px 15px 0 rgba(0, 0, 0, 0.50);
    max-width: 675px;
    margin: 0 auto;
    background: #fff;
    margin-top: 50vh;
    transform: translateY(-50%);
    max-height: 100%;

}

.form-modal .modal {
    max-width: 800px;
    border-radius: 30px;
    overflow-x: auto;
    overflow-y: auto;
}

.hcp-modal .modal {
    max-width: 530px;
    background: none;
    box-shadow: none;
    position: relative;
}

.ty-modal .modal {
    max-width: 430px;
    background: none;
    box-shadow: none;
    position: relative;
}

.hcp-modal .modal .bg,
.ty-modal .modal .bg {
    position: absolute;
    top: 50%;
    left: 50%;
    transform: translate(-50%, -50%);
    border-radius: 100%;
}

.hcp-modal .modal .inner,
.ty-modal .modal .inner {
    position: relative;
    z-index: 10;
    text-align: center;
}

.hcp-modal .modal .inner p {
    max-width: 375px;
    margin: 20px auto;
}

.form-modal .title {
    color: var(--Blue, #0047C7);
    font-family: "Open Sans";
    font-size: 24px;
    font-style: normal;
    font-weight: 800;
    line-height: normal;
    display: block;
    margin-bottom: 30px;
    padding-right: 40px;
}

.ty-modal .modal .title {
    display: block;
    color: var(--Blue, #0047C7);
    text-align: center;
    font-family: "Open Sans";
    font-size: 33.117px;
    font-style: normal;
    font-weight: 800;
    line-height: normal;
    margin: 20px 0;
    display: block;
}

.form-modal .subtitle {
    color: var(--Icon-Gray, #50534C);
    font-family: "Open Sans";
    font-size: 20px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
}





.modal .row {
    margin: 15px 0 0 0;
}

.modal .inner {
    padding: 30px;
}

.modal p {
    margin: 0;
    color: #50534C;
}

.modal .col:first-child {
    width: 60%;
}

.modal .col.end {
    flex: 1;
    text-align: right;
}

.cookie-modal.hide,
.form-modal.hide,
.hcp-modal.hide,
.ty-modal.hide {
    display: none;
}



.form-modal .row {
    display: flex;
    margin: 0 -12px;
    align-items: center;
}

.form-modal .row .input-wrap {
    width: 50%;
    padding: 8px 12px;
}

.form-modal .row .input-wrap input,
.form-modal .row .input-wrap select {
    border-radius: 4px;
    border: 1px solid #DFDFDF;
    background: #F4F4F4;
    display: block;
    width: 100%;
    font-size: 16px;
    padding: 15px 10px;
}

.form-modal .row .input-wrap select,
.form-modal .row .input-wrap input::placeholder {
    color: #333;
}


.form-modal .tancs p,
.form-modal .tancs ul li {
    font-size: 11px;
}

.form-modal .tancs p {
    margin: 0;
}

.form-modal .tancs ul {
    margin: 0;
}

.form-modal .tancs a {
    font-weight: normal;
}

.form-modal .btn {
    margin-bottom: 0;

}

.form-modal .button-bar-form {
    margin: 20px 0;
}

.form-modal .button-bar-form button:nth-child(2) {
    margin-left: 10px;
}


@media screen and (max-width:800px) {
    .form-modal .row {

        flex-wrap: wrap;

    }

    .form-modal .row .input-wrap {
        width: 100%;

    }

    .form-modal {
        margin: 10px;
        height: calc(100vh - 20px);
        width: calc(100vw - 20px);
    }

}

@media screen and (max-width:800px) {

    h2 {
        padding: 0 20px;
    }




    .utility {
        padding: 20px 0;
    }

    .utility .row {
        align-items: center;
    }

    .utility .col {
        width: 100%;

    }

    .utility .txt-r {
        text-align: center;
        flex: auto;
    }

    .utility ul li {
        width: calc(50% - 30px);
        line-height: 1;
        padding: 5px 5px 0 5px;
    }

    .hcp-text {
        font-size: 10px;
    }



}


@media screen and (max-width:800px) {

    .hero {
        padding: 20px 0px 0 0px;
        background-image: url('./images/mobile-background-NEW.png');
        width: 100%;
    }

    .hero-404 {
        padding: 8vh 60px 8vh 60px !important;
    }

    .hero-404 .title {
        font-size: 32px !important;
        line-height: 1.1;
    }

    h1 {
        font-size: 36px;
    }


    .wrapper .row .col.w-3 {
        width: 100%;
        margin-top: 30px;
    }

    .hero p {
        padding: 0 4%;
    }

    .hero .btn {
        margin-bottom: 40px;
    }




}

@media screen and (max-width:800px) {
    .isi .title {
        padding-right: 30px;
    }

    .isi.fixed {

        height: calc(11em + 30px);

    }

    #sticky-isi:not(.expanded) {
        max-height: 170px;
    }
}



@media screen and (max-width:800px) {
    footer .row .col {
        order: 1;
        text-align: center;
    }

    footer .row .col.end {
        order: 2;
    }

    footer .col,
    footer .col.end {
        width: 100%;
        flex: auto;
    }

    .footer-nav {
        text-align: center;

        margin-top: 20px;
        margin-bottom: 10px
    }

    .footer-nav li {
        display: block;
        margin: 35px 0;
    }

    .footer-nav li:first-child {
        margin-top: 0;
    }

    .footer-nav li:last-child {
        margin-bottom: 0;
    }

    .footer-nav li:not(:last-child):after {
        display: none;
    }


    .modal .col:first-child {
        width: 100%;
        padding: 10px 0;
    }

    .modal .col.end {
        flex: 1;
        padding: 10px 0;
    }


}


.hero-404 {

    padding: 25vh 0 25vh 0;
    background-image: url('./images/404-bg.png');
    background-position: center;
    background-repeat: no-repeat;
    background-size: cover;
    text-align: center;
}

.hero-404 .title {
    color: #002973;
    font-weight: 900;
    font-size: 44px;
    display: block;
    text-transform: uppercase;
}

.hero-404 p {
    font-weight: bold;
    font-size: 13px;
    color: #50534C;
}


.enrollement {
    max-width: 800px;
    margin: 80px auto;
    display: flex;
    align-items: center;
}

.enrollement>div {
    padding: 0 20px;
}

.enrollement .icon {
    border-right: 1px solid #EA7603;
    width: 130px;
}

.enrollement .content {

    display: flex;
    align-items: flex-end;
    flex-wrap: wrap;
    flex: 1;

}

.enrollement .content>div:first-child {
    padding-right: 20px;
    width: calc(100% - 230px);
}

.enrollement h3 {
    font-size: 22px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    letter-spacing: -0.5px;
    margin-bottom: 10px;
    color: #EA7603;
    margin-top: 0;
}

.enrollement p {
    margin-top: 5px;
    margin-bottom: 0;
}

.enrollement .button {
    width: 230px;
    text-align: right;
}

.enrollement .content .inner-content a {
    text-decoration: underline;
}

.enrollement .button .btn {
    margin: 0;
    padding: 10px 25px;
}

.enrollement .button .btn img {
    vertical-align: middle;
}

@media screen and (max-width: 800px) {
    .enrollement .content div.inner-content {
        width: 100%;
        padding-right: 0px;
    }

    .enrollement .content .button {
        width: 100%;
        text-align: left;
        margin-top: 10px;
    }



    .enrollement .icon {
        width: 100px;
    }

    .enrollement .icon img {
        width: 100%;
    }

    .enrollement {
        align-items: normal;
    }

}

.nowrap {
    white-space: nowrap;
}



.mymeso {

    border-radius: 0px 0px 40px 40px;
    background: linear-gradient(180deg, #FFF 0%, #E8F1FA 100%);
    box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    padding: 45px var(--Section-2-L-R-Padding);
    position: relative;
    z-index: 2;
    margin-top: -30px;
}

.mymeso h2 {
    color: var(--Blue, #0047C7);
    text-align: center;
    font-size: 24px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    letter-spacing: -0.75px;
    margin: 0;
}

.mymeso .icon-section {
    display: flex;
}

.mymeso .icon-section>div {
    padding: 0 20px;
    margin-top: 30px;
}

.mymeso p {
    letter-spacing: -0.5px;
}

.mymeso ul li {
    margin: 8px 0;
    font-weight: bold;
}

ul li::marker {
    color: #0047C7;
}

.mymeso .icon-section .icon {
    width: 180px;
    text-align: right;
    border-right: 1px solid #EA7603;
}

.mymeso .icon-section .content {
    flex: 1;
}

.mymeso h3 {
    color: var(--Dark-Orange, #EA7603);
    font-family: "Open Sans";
    font-size: 22px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    letter-spacing: -0.5px;
}

.mymeso .btn {
    margin: 0;
}

.mymeso .btn img {
    vertical-align: middle;
}

.mymeso .content .flex {
    display: flex;
    align-items: center;
}

.mymeso .content .flex .button-sec {
    width: 240px;
    text-align: right;
}

.mymeso .content .flex .inner-content {
    flex: 1;
    padding-right: 10px;
}



@media screen and (max-width:800px) {
    .mymeso {

        padding: 45px 20px;

    }

    .mymeso .icon-section {
        flex-wrap: wrap;
    }

    .mymeso .icon-section .icon {
        width: 100%;
        text-align: center;
        border-right: 0px;

    }

    .mymeso .content .flex {
        flex-wrap: wrap;
    }

    .mymeso .content .flex .button-sec {
        width: 100%;
        text-align: center;
    }

    .mymeso .content .flex .inner-content {
        flex: 1;
        padding-right: 0px;
    }

    .mymeso #howtoorder {
        text-align: center;
    }



}



.resources {
    border-radius: 0px 0px 40px 40px;
    background: #F9F9F9;

    box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    padding: var(--Section-3-Section-3-T-B-Padding, 50px) var(--Section-3-Section-3-L-R-Padding, 40px) 39px var(--Section-3-Section-3-L-R-Padding, 40px);
    flex-direction: column;
    align-items: center;
    gap: -20px;
    align-self: stretch;
    margin-top: -20px;
}

.resources-section {
    border-top: 1px dashed #bbb;
    text-align: center;
    padding: 40px 0;

}

.resources-section a {
    text-decoration: underline;
}

.resources-section h3 {
    color: var(--Dark-Orange, #EA7603);
    text-align: center;
    font-family: "Open Sans";
    font-size: 18px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    margin: 5px 0 0 0;
}

.resources-section p {

    max-width: 90%;
    margin: 10px auto 20px auto;
}


.resources-section .flex {
    display: flex;
    margin: 0 -20px;
    flex-wrap: wrap;
    justify-content: center;
}

.resources-section .flex .col {
    width: 33.333%;
    padding: 0 20px;
    text-align: center;
}

.resources-section .icn {
    height: 32px;
}


@media screen and (max-width:800px) {

    .resources {
        padding: 50px 20px;
    }

    .resources-section .flex .col {
        width: 100%;
        text-align: center;
        margin: 20px 0;
    }

}


.custom-select {

    border-radius: 20px;
    border: 0.5px solid #979797;

    background: #FFF;

    position: relative;
    max-width: 350px;
    margin: 0 auto;

}

.custom-select .dropdown {
    overflow: hidden;
    max-height: 0px;
    position: absolute;
    top: 100%;
    left: -1px;
    width: calc(100% + 2px);
    background: #FFF;
    transition: max-height, border .3s ease;
}

.custom-select .dropdown div {
    padding: 15px 20px;
    text-align: left;
    position: relative;
}

.custom-select .dropdown div svg {
    position: absolute;
    width: 100%;
    bottom: 0;
    left: 0;
}

.custom-select .dropdown div a {
    color: #767676;
    font-family: "Open Sans";
    font-size: 15px;
    font-style: normal;
    font-weight: 600;
    line-height: normal;
}

.custom-select .title {
    font-size: 16px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    color: #767676;
    position: relative;
    padding: 12px 20px;
    text-align: left;
}

.custom-select .title img {
    position: absolute;
    right: 20px;
    top: 50%;
    transition: all .3s ease;
    transform: translateY(-50%) rotate(180deg);
}

.custom-select.active .title img {
    transform: translateY(-50%) rotate(0deg);
}

.custom-select.active {
    border-radius: 20px 20px 0 0;
    border-bottom: 0;

}

.custom-select.active .dropdown {
    max-height: 1000px;


    transition: max-height .3s ease-in;
    border: 0.5px solid #979797;
    border-top: 0;

    box-shadow: 0px 4px 4px 0px rgba(0, 0, 0, 0.25);
    border-radius: 0px 0px 20px 20px;
}


.treatment-center {
    margin: 60px auto;
    max-width: 890px;

}

.treatment-center .flex {
    display: flex;
    margin: 0 -20px;
}

.treatment-center .flex>div {
    padding: 0 20px;
}

.treatment-center .flex .vial {
    width: 170px;
    text-align: right;
    border-right: 1px solid #EA7603;
}

.treatment-center .flex .content {
    flex: 1;
}

.treatment-center h3 {
    color: var(--Dark-Orange, #EA7603);
    font-family: "Open Sans";
    font-size: 22px;
    font-style: normal;
    font-weight: 700;
    line-height: normal;
    letter-spacing: -0.5px;
    margin-top: 0;

}

.treatment-center .flex .flex {
    align-items: center;
}

.treatment-center .flex .button-sec {
    width: 300px;
}

.treatment-center .flex .inner-content {
    flex: 1;
}

@media screen and (max-width:800px) {

    .treatment-center .flex {
        flex-wrap: wrap;
        text-align: center;
    }

    .treatment-center .flex .vial {
        width: 100%;
        text-align: center;
        border-right: 0px solid #EA7603;
    }

    .treatment-center .flex .vial img {
        margin-left: -60px;
    }

    .treatment-center .flex .button-sec {
        width: 100%;
    }

    .treatment-center .flex .inner-content {

        padding: 0 0px;
    }

    .treatment-center .flex .inner-content p {
        margin: 10px auto;
    }

    .treatment-center .flex {
        margin: 0;
    }

    .treatment-center h3 {
        font-size: 20px;
    }


}